과제정보
This work was carried out with the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ017090052022)" Rural Development Administration, Republic of Korea.
한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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- Pages.47-47
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- 2023
Immune-enhancing Activity of Paeonia lactiflora through TLR4-dependent Activation of p38, JNK, and ERK1/2 RAW264.7 Cells
- Jeong Won Choi (Department of Forest Science, Andong National University) ;
- Hyeok Jin Choi (Department of Forest Science, Andong National University) ;
- Gwang Hyeon Ryu (Department of Forest Science, Andong National University) ;
- Seung Woo Im (Department of Forest Science, Andong National University) ;
- Jae Won Lee (Department of Forest Science, Andong National University) ;
- Jin Boo Jeong (Department of Forest Science, Andong National University)
- 발행 : 2023.04.27
초록
Paeonia lactiflora roots (PLR) are a medicinal plant widely used for treating inflammatory diseases. However, PLR has been recently reported to increase the production of proinflammatory mediators and activates phagocytosis in macrophages. Thus, in this study, we tried to verify the macrophage activation of PLR and elucidate its mechanism of action. PLR upregulated the production of proinflammatory mediators and activated phagocytosis in RAW264.7 cells. However, these effects were reversed by inhibition of TLR2/4. In addition, the inhibition of p38, JNK, and ERK1/2 reduced the PLR-mediated production of proinflammatory mediators, and the PLR-mediated activation of p38, JNK, and ERK1/2 was blocked by the TLR4 inhibition. These findings indicate that PLR may activate macrophages through TLR4-dependent activation of p38, JNK, and ERK1/2. These indicate that PLR has immunostimulatory activity. Thus, it is believed that PLR can be used as a functional food agent that enhances the immune system.
키워드