과제정보
This work was supported by R&D Program for Forest Science Technology (Project No. 2021377C10-2123-BD02) provided by Korea Forest Service (Korea Forestry Promotion Institute).
한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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- Pages.44-44
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- 2023
Immunostimulatory Activity of Syneilesis palmata Leaves through Macrophage Activation and Macrophage Autophagy
- Jeong Won Choi (Department of Forest Science, Andong National University) ;
- Hyeok Jin Choi (Department of Forest Science, Andong National University) ;
- Gwang Hyeon Ryu (Department of Forest Science, Andong National University) ;
- Seung Woo Im (Department of Forest Science, Andong National University) ;
- Jae Won Lee (Department of Forest Science, Andong National University) ;
- Jin Boo Jeong (Department of Forest Science, Andong National University)
- 발행 : 2023.04.27
초록
Syneilesis palmata (SP) has been used as a traditional medicinal plant and vegetable. SP was reported to exert pharmacological activities such as anti-inflammation, anti-cancer, and anti-HIV. However, there are no studies on the immunostimulatory activity of SP. Thus, in this study, we report that S. palmata leaves (SPL) induce the activation of macrophages. An increase in both secretions of immunostimulatory mediators and phagocytotic activity was observed in SPL-treated RAW264.7 cells. However, this was reversed by inhibition of TLR2/4. In addition, the p38 inhibition reduced the SPL-mediated secretion of immunostimulatory mediators, and the SPL-mediated p38 activation was blocked by the TLR2/4 inhibition. SPL augmented both p62/SQSTM1 and LC3-II. TLR2/4 inhibition blocked the SPL-mediated increase of p62/SQSTM1 and LC3-II. These findings indicate that SPL may activate macrophages through TLR2/4-dependent p38 activation and activate autophagy through TLR2/4 stimulation.
키워드