과제정보
본 연구는 농촌진흥청(사업번호: PJ016243022021)의 지원에 의해 이루어진 결과로 이에 감사드립니다.
한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2022년도 추계학술대회
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- Pages.30-30
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- 2022
데커시놀 파생물질들의 항징균제로서의 활용
Useful Applications Decursinol Derivatives as Biochemical Fungicides
- 신윤정 (서울대학교 농업생명과학대학) ;
- 신지영 (서울대학교 농업생명과학대학) ;
- 장혜원 (서울대학교 농업생명과학대학) ;
- 손호경 (서울대학교 농업생명과학대학) ;
- 권용훈 (서울대학교 농업생명과학대학)
- Yun-Jeong Shin (Department of Agricultural Biotechnology, Seoul National University) ;
- Jiyoung Shin (Department of Agricultural Biotechnology, Seoul National University) ;
- Hyewon Jang (Department of Agricultural Biotechnology, Seoul National University) ;
- Hokyoung Son (Department of Agricultural Biotechnology, Seoul National University) ;
- Yonghoon Kwon (Department of Agricultural Biotechnology, Seoul National University)
- 발행 : 2022.09.27
초록
Natural products decursin and decursinol angelate were recently reported as benign fungicides for controlling rice blast. Inspired by the structural similarity of the cumarin compounds and gained hint from the skeletal motifs, we designed and prepared synthetic compounds to increase the natural product efficacy and evaluated their antifungal activities against various plant disease pathogens in vitro. Synthetically prepared compound 4 and 5 indeed suppressed the mycelial growth of B. cinerea, F. oxysporum, P. italicum, and R. quercus-mongolicae. Additionally, compound 5 effectively prevents the growth of C. coccodes and C. parasitica. Furthermore, both 4 and 5 possess better inhibitory activities on spore germination of F. oxysporum and M. oryzae than the natural product decursin. These results suggest that the effect of the lead compound for plant disease protection can be improved by tuning the structure of the original natural product and decursinol chloroacrylates 4 and 5 are candidates for the control of F. oxysporum and M. oryzae.
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