Acknowledgement
Supported by : National Research Foundation of Korea(NRF)
Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2019.04a
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- Pages.117-117
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- 2019
Inhibitory effects of Kirengeshoma koreana Nakai on Melanogenesis in B16F10 melanoma cells
- Jang, Tae-Won (Medicinal Plant Resources, Andong National University) ;
- Choi, Ji-Soo (Medicinal Plant Science, Jungwon University) ;
- Mun, Jeong-Yun (Pharmaceutical Science, Jungwon University) ;
- Im, Jong-Yun (Pharmaceutical Science, Jungwon University) ;
- Nam, Su-Hwan (Baekdudaegan National Arboretum, Division of Education Service) ;
- Kim, Do-Wan (Food Science, Jungwon University) ;
- Lee, Seung-Hyun (Industry-Academic Cooperation Foundation, Jungwon University) ;
- Park, Jae-Ho (Medicinal Plant Science, Jungwon University)
- Published : 2019.04.25
Abstract
Kirengeshoma koreana Nakai (K. koreana)was Saxifragaceae and rare plants in Korea, which is classified as an Critically Endangered (CR) species in Korea. Therefore, most of the studies on it were ecological and taxonomic, and there are no studies on biological activity. In this study, we evaluated the whitening activity of K. koreana extract (KKE). Melanogenesis Inhibitory effects were demonstrated by western-bot and RT-PCR for the effects of KKE on MITF, tyrosinase, TRP-1 and TRP-2 in IBMX-treated B16F10 melanoma cells. IBMX were reported as melanin synthesis enhancers. It could increase intracellular melanin synthesis by activation of the microphthalmia-associated transcription factor (MITF) signaling pathway. KKE showed no cytotoxicity at B16F10. In addition, KKE effectively inhibited the protein and mRNA levels of MITF, tyrosinase, TRP-1 and TRP-2. In conclusion, KKE inhibited melanin synthesis by inhibiting the expression of MITF and its downstream pathways tyrosinase, TRP-1 and TRP-2. Therefore, it was confirmed that K. koreana is a valuable resource for functional cosmetic and biomaterials.
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