Proceeding of EDISON Challenge (EDISON SW 활용 경진대회 논문집)
- 2016.03a
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- Pages.62-66
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- 2016
Structural and Thermodynamic Characteristics of cHLH Peptide and cHLH/HDM2 Complex
- Im, Haeri (Department of Chemistry, Sookmyung Women's University) ;
- Cho, Sunhee (Department of Chemistry, Sookmyung Women's University) ;
- Ham, Sihyun (Department of Chemistry, Sookmyung Women's University)
- Published : 2016.03.22
Abstract
Tumor suppressor protein p53 loses its function upon binding with the HDM2 protein, and inhibiting the p53-HDM2 interaction is critical to suppress tumor cell growth. Recently, the cyclized helix-loop-helix peptide (cHLH) mimicking the
Keywords
- Cyclized Helix-Loop-Helix;
- Protein-Protein Interaction;
- Molecular Dynamics Simulations;
- Solvation Free Energy