Proceedings of the Korean Vacuum Society Conference (한국진공학회:학술대회논문집)
- 2015.08a
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- Pages.161.2-161.2
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- 2015
Influence of atmospheric pressure plasma on the melanogenesis in melanoma cells
- Ali, Anser (Department of Plasma-Bio Display, Kwangwoon University) ;
- Lee, SeungHyun (Department of Plasma-Bio Display, Kwangwoon University) ;
- Attri, Pankaj (Department of Plasma-Bio Display, Kwangwoon University) ;
- Choi, Eun Ha (Department of Plasma-Bio Display, Kwangwoon University)
- Published : 2015.08.24
Abstract
Melanin is a black pigment, responsible for hair and skin color. In order to find the melanin stimulatory technique which prove useful for a gray and a white hair-preventive agent or tanning agent, we developed atmospheric pressure plasma jet (APPJ) and tested for tyrosinase activity and melanin production in melanoma (B16F10) cells in vitro. We found plasma dose dependent increase in melanin production. To explore the contributing mechanism in melanin synthesis, intracellular reactive oxygen species (ROS) and MAP kinase signaling pathways were studied. Furthermore, the development of plasma technology for melanin synthesis and planning for in-vivo future studies will be discussed.
Keywords
- Melanoma cells;
- Melanin;
- Tyrosinase;
- Intracellular reactive oxygen species;
- Atmospheric pressure plasma jet