한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2012년도 정기총회 및 춘계학술발표회
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- Pages.20-20
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- 2012
인삼에서의 트리터페노이드 진세노사이드의 생합성
Triterpenoid Ginsenoside Biosynthesis in Panax ginseng C. A. Meyer
- Kim, Yu-Jin (Department of Oriental Medicinal Materials and Processing, College of Life Science, Kyung Hee University) ;
- Lee, Ok-Ran (Department of Oriental Medicinal Materials and Processing, College of Life Science, Kyung Hee University) ;
- Yang, Deok-Chun (Department of Oriental Medicinal Materials and Processing, College of Life Science, Kyung Hee University)
- 발행 : 2012.05.11
초록
Isoprenoids represent the most diverse group of metabolites, which are functionally and structurally identified in plant organism to date. Ginsenosides, glycosylated triterpenes, are considered to be the major pharmaceutically active ingredient of ginseng. Its backbones, categorized as protopanaxadiol (PPD), protopanaxatriol (PPT), and oleanane saponin, are synthesized via the isoprenoid pathway by cyclization of 2,3-oxidosqualene mediated with dammarenediol synthase or beta-amyrin synthase. The rate-limiting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), which is the first committed step enzyme catalyzes the cytoplasmic mevalonate (MVA) pathway for isoprenoid biosynthesis. DXP reductoisomerese (DXR), yields 2-C-methyl-D-erythritol 4-phosphate (MEP), is partly involved in isoprenoid biosynthesis via plastid. Squalene synthase and squalene epoxidase are involved right before the cyclization step. The triterpene backbone then undergoes various modifications, such as oxidation, substitution, and glycosylation. Here we will discuss general biosynthesis pathway for the production of ginsenoside and its modification based on their subcellular biological functions.