Proceedings of the Materials Research Society of Korea Conference (한국재료학회:학술대회논문집)

Materials Research Society of Korea (한국재료학회)
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Biocompatibility of oxidized alginate/gelatin/BCP -based hydrogel composites

  • Phuong, Nguyen Thi (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Min, Young-Ki (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Yang, Hun-Mo (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Song, Ho-Yeon (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Teak (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University)
  • Published : 2010.05.13
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Abstract

In this study, oxidized alginate/gelatin/biphase calcium phosphate (BCP)- based hydrogel composites were fabricated. Alginate sodium was oxidized by periodate. The oxidized product was confirmed by using $^1H$ and $^{13}C$ NMR spectra. The number average molecular weight ($M_n$), the average molecular weight ($M_w$) of the oxidized alginate were determined by Gel Permeation Chromatography (GPC). The hydrogel was formed from the oxidized alginate and gelatin solution via Schift-base reaction. The hydrogel showed a highly porosity by a Scanning Electron Microscope (SEM) and Mercury Intrusion Porosimetry (MIP). Crosslinked density of the gel matrix were assessd by trinitrobenzene sulfonic acid (TNBS) assay that shows a high effect on swelling ratio. Increment of the crosslinked desity resulted in enhancing compressive strength of the hydrogel composite. The cytotoxity of hydrogel was assessed with osteoblast MG-63. The hydrogel composites show a high compatibility. The obtained results showed a potential application for bone regeneration in future.

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