The major limitation of the traditional Intelligent Tutoring Systems (ITS) is that interface is mainly focused on the cognitive factors. However, the new direction of ITS is shifting form the cognitive perspectives to the motivational perspectives reflecting the individual differences. In this study, the specific design guidelines for motivational interface of ITS are proposed to promote learner's motivation to learn during the interaction with the ITS. First, ITS should be able to reflect individual differences in cognitive abilities, interest and motivation, and ongoing changes of the interestingness and comprehensibility during learning activities. Second, it is essential for ITS to guarantee learner controllability, diverse learning activities, curiosity, self-relevance, and challenge to enhance the level of motivation and situational interest. Third, the game-like properties are also needed to maximize the motivational effect of learning with ITS.