Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
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Supramolecular assembly of peptide molecules for applications in biological multivalent interactions

  • Lim, Yong-Beom (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University) ;
  • Park, So-Mi (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University) ;
  • Lee, Eun-Ji (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University) ;
  • Jeong, Hae-Mi (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University) ;
  • Ryu, Ja-Hyoung (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University) ;
  • Yang, Won-Young (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University) ;
  • Lee, Myong-Soo (Center for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University)
  • Published : 2006.10.13
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Abstract

Multivalent interactions, which are characterized by the simultaneous binding of multiple ligands on multiple receptors, are prevalent in biological system. We have shown that it is able to make a supramolecular aggregate coated with multiple functional molecules fairly easily by simply mixing one building block. In this particular example, a mannose-coated object was able to agglutinate bacterial cells with cognate binding partners through multivalent interactions. This kind of strategy can be applied in developing materials that can selectively remove pathogens. Supramolecular assembly of this type should be very useful in exploring multivalent biological interactions.

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