Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
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Effect of Crosslinking on Release of Model Drug from Electrospun Poly(vinyl alcohol) Fiber Mats

  • Taepaiboon, Pattama (Technological Center for Electrospun Fibers and The Petroleum and Petroleum College, Chulalongkorn University) ;
  • Rungsardthong, Uracha (National Nanotechnology Center, Thailand Science Park) ;
  • Supaphol, Pitt (Technological Center for Electrospun Fibers and The Petroleum and Petroleum College, Chulalongkorn University)
  • Published : 2006.10.13
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Abstract

Electrospun fibers of poly(vinyl alcohol) (PVA) were successfully prepared and applied as drug carriers for transdermal drug delivery system. Sodium Salicylate (SS) was the model drug and it was incorporated in the PVA fibers by adding 20 % of SS in a PVA solution prior to electrospinning. Electrospinning of SS-containing PVA solution resulted in the formation of beaded fibers. In order to control the rate of SS release and decrease water solubility of PVA, the SS-loaded electrospun PVA mat was cross-linked by either glutaraldehyde or glyoxal vapor. The morphology, thermal behavior, swelling behavior, release characteristic, kinetics of drug release and also toxicity of the cross-linked sample were investigated.

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