Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)
- 2006.10a
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- Pages.56-57
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- 2006
Ultra pH-Sensitive Polymeric Nanosystems for Tumor Targeting and chemotherapy
- Lee, Eun-Seong (Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah) ;
- Na, Kun (Division of Biotechnology, The Catholic University of Korea) ;
- Bae, You-Han (Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah)
- Published : 2006.10.13
Abstract
The ultra pH-sensitive polymeric mixed micelles based on poly(L-histidine) chemistry and constructed from block copolymers containing polyHis, present four functionalities as decreasing pH: ligand exposure at pH 7.0, micelle destabilization below pH 6.8, enhanced DOX release and endosomal membrane disruption. The first functionality is expected to endow tumor pH specificity to nonspecific ligands and the rest ones may help to treat solid tumors that are hard-to-treat by conventional chemotherapy (resistant tumors). The concept was proven in vitro studies and in vivo model.
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