한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Inhibition Effect of Gleditsia Sinensis Lam on T tyrosinase Activity and Reactive Oxygen Species related to Melanin Biosynthesis

  • Kim, Yeon-Zu (Department of Gwangju Health College) ;
  • Kim, Jin (Interdisciplinary Program of Perfume and Cosmetic, Chonnam National University) ;
  • Park, Hee-Jung (Department of Material & Biochemical Engineering, Chonnam National University) ;
  • Lee, Chang-Moon (Interdisciplinary Program of Biomedical Engineering, Chonnam National University) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering, Chonnam National University)
  • Published : 2005.04.15
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Abstract

Recently many efforts have been made to develop new therapeutic agents against skin pigmentation abnormalities. The aim of this study is to investigate the skin-whitening effect of Gleditsia Sinensis Lam and to develop new drug delivery carrier. Inhibitory effaces of Gleditsia Sinensis Lam extracts on melanin synthesis were studied. Namely, UV-absorbing ability, free radical scavenging activity and tyrosinase inhibitory of Gleditsia Sinensis Lam extracts were investigated As a result, the extracts of Gleditsia Sinensis Lam were found to inhibit the activity of tyrosinase. Moreover they absorbed wavelength in the UV-B and UV-C region, and extracts of Gleditsia Sinensis Lam had free radical scavenging activity. In this study, in order to administer these ingredient effectively, the shape of liposome observed by TEM was spherical and uniform.

조협은 trosinase 저해 활성 실험 결과 1.9%(w/v) 이상의 농도에서 70%이상의 저해를 나타내고, UV 흡수능에서는 220-230nm 에서 최대 흡수 파장이 나타나고 250-550nm 에서 고르게 흡수되는 경향을 보인다. 조협은 자외선 차단효과와 활성산소종 형성 억제 및 멜라닌 생성을 저해함으로써 피부미백 효과에 기여한다. 따라서 조협을 이용한 liposome을 제조하여 미백화장품에의 응용 가능성을 높여 줄 수 있다.

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