Proceedings of the Korean Environmental Health Society Conference (한국환경보건학회:학술대회논문집)
- 2005.06a
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- Pages.345-350
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- 2005
Preliminary Risk Assessment of Several Major Pharmaceutical Products In Aquatic Ecosystem
- Park, Su-Jung (School of Public Health, Seoul National University) ;
- Oh, So-Rin (School of Public Health, Seoul National University) ;
- Jung, Jin-Yong (School of Public Health, Seoul National University) ;
- Kim, Young-Hee (School of Public Health, Seoul National University) ;
- Kim, Pan-Gyi (Yongin University) ;
- Choi, Kyung-Ho (School of Public Health, Seoul National University)
- Published : 2005.06.03
Abstract
Acute toxicities of five pharmaceutical products were evaluated with aquatic microbes, invertebrates, and fish. The test pharmaceuticals, i.e., cimetidine, carbamazepine, diltiazem, acetaminophene, and metformin have been often detected in aquatic environment, but theire cological hazard on receptors of various trophic levels has seldom been evaluated. In the present study, we conducted acute toxicity assays with a marine bacterium, Vibrio fischeri, an invertebrate, Daphnia magna, and a fish, Japanese medake (Oryzias latipes). In general, D. magna, showed the most sensitive response to the test chemicals. Diltiazem exhibited the lowest EC50 value after 96 hr of exposure at 7.6 mg/L, followed by cimetidine >acetaminophen > metformin = carbamazepine in an order of decreasing susceptibility. With the fish, diltiazem and carbamazepine showed the 96 hr EC50 values at 14.1
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