Pulmonary Toxicity of Single Walled Carbon Nanotubes

  • Published : 2005.05.01

Abstract

A. Nebulized SWCNT dispersed as aggregates and nanotubes B. Aspiration causes transient oxidant stress, damage and inflammation, peaking by 7 days post-exposure C. Histology visualizes aggregates in the tirminal bronchials and proximal alveli with no visible material in distal alve oli D. Size of aggregates doesn't change with time E. Rapid fibrosis - begins in 7 days and progresses through 60 day post-exposure 1) Fibrosis in granulomatous lesions containing aggregates 2) Diffuse interstitial fibrosis in distal alveolar walls with no visible SWCNT F. Used silver enhancement of gold-labeled SWCNT 1) See aggregates in proximal alveoli and terminal bronchials 2) See nanoropes in walls of distal alveoli

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