Proceedings of the Korean Environmental Health Society Conference (한국환경보건학회:학술대회논문집)
- 2004.06a
- /
- Pages.185-187
- /
- 2004
The Estrogenicity and Reproductive Toxicity by Combined Treatment of Bisphenol A and Benzyl butyl phthalate during Gestation, Lactation Period in Rats
- Hwang, Seong-Hee (Department of Environmental Health, Yongin University) ;
- Kim, Jeong-Hyun (Department of Environmental Health, Yongin University) ;
- Kang, Hee-Joo (Department of Environmental Health, Yongin University) ;
- Kim, Hyun-Soo (Department of Environmental Health, Yongin University) ;
- Kim, Kyong-Tae (Department of Environmental Health, Yongin University) ;
- Kim, Pan-Gyi (Department of Environmental Health, Yongin University)
- Published : 2004.06.04
Abstract
The co-administration of BPA and BBP induced slow weight gain compared with single administration in dams. Also, such mixture induced low neonatal body weights in next generation. The dams treated with BPA and BBP showed significant organ weight changes in liver, spleen exposed during lactational periods. But the dams exposed during lactational periods showed significant organ weight changes not only in liver, spleen but also in kidney, uterus and ovary. The F1 female rats exposed during lactation periods showed significant organ weight changes in liver, spleen, ovary. The F1 male rats showed significant organ weight changes in liver, kidney, epididymis, vesicular glands, prostate. However no clear synergistic effects of BPA and BBP could be found. Estrogen receptor
Keywords