Proceedings of the Korean Society of Food Science and Nutrition Conference (한국식품영양과학회:학술대회논문집)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Resveratrol on Coxsackie Virus B3m-induced Myocarditis in Mice

  • Dong Hao-Han (Cardiovascular Section, Yue Yang Hospital, affiliated with Shanghai University of Traditional Chinese Medicine) ;
  • He-Li Ren (Cardiovascular Section, Yue Yang Hospital, affiliated with Shanghai University of Traditional Chinese Medicine)
  • Published : 2004.11.01
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Abstract

To observe the intervening effect of resveratrol on coxsackie virus B3m-induced myocarditis in Balb/c mice and explore the mechanism of intervening effect. Using an animal model of viral myocarditis induced by coxsackie virus B3m (CVB3m), with Ribavirin and Astragalan as comparison, to examine the changes of general condition, mortality, the weights of heart, liver and spleen, serum MDA and NO levels, and cardiac histology in Balb/c mice. By comparison with Ribavirin and Astragalan, it was found that in the mice model of viral myocarditis induced by coxsackie virus B3m resveratrol significantly improved the changes of general condition, mortality, the weights of heart, liver and spleen, serum MDA and NO levels, and cardiac histology. It suggested that resveratrol may have some chemopreventive and chemotherapeutic effects in the treatment of viral myocarditis.

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