한국동물번식학회:학술대회논문집 (Proceedings of the KSAR Conference)
- 한국동물번식학회 2004년도 춘계학술발표대회
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- Pages.274-274
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- 2004
Improvement of Motor Behavior of Parkinson's Disease Animal Model by Nurr1 Transfected Human Embryonic Stem Cells
- Lee, Chang-Hyun (Maia Infertility Hospital Medical Institute/Maria Biotech) ;
- Cho, Hwang-Yun (Maia Infertility Hospital Medical Institute/Maria Biotec) ;
- Kim, Yong-Sik (Seoul National University, College of Medicin) ;
- Kim, Eun-Young (Maia Infertility Hospital Medical Institute/Maria Biotec) ;
- Lee, Won-Don (Maria Infertility Hospita) ;
- Park, Sepill (Maia Infertility Hospital Medical Institute/Maria Biotec) ;
- Lim, Jin-Ho (Maria Infertility Hospital)
- 발행 : 2004.06.01
초록
The purpose of this study is to evaluate the efficacy of in vitro differentiated human embryonic stem (MB03) cells expressing Nurr1 in relief of symptomatic motor behavior of Parkinson's disease (PD) animal models. MB03 cell was genetically modified to express Nurr1 protein (Nr#24/MB03) and was induced to differentiate according to 2- /4+ protocol using retinoic acid and ascorbic acid. (omitted)