Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Heme Oxygenase Inducers from Natural Products

  • Chung, Hun-Taeg (Department of Microbiology and Immunology, Wonkwang University School of Medicine) ;
  • Pae, Hyun-Ock (Department of Microbiology and Immunology, Wonkwang University School of Medicine) ;
  • Park, Byung-Min (Department of Microbiology and Immunology, Wonkwang University School of Medicine) ;
  • Oh, Gi-Su (Department of Microbiology and Immunology, Wonkwang University School of Medicine)
  • Published : 2004.04.01
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Abstract

Heme oxygenase (HO)-l catabolizes heme into three products: carbon monoxide, bilirubin, and free iron. HO-l serves as a protective gene by virtue of the anti-inflammatory, anti-apoptotic and anti-proliferative actions of one or more of these three products. HO-l can be regarded as a potential therapeutic target in a variety of oxidant-mediated and inflammatory diseases. In this respect, it would be valuable to develop potent and selective inducers of HO-1 for therapeutic use. Here, we have shown that 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, catalposide and dehydrocostus lactone are potent inducers of HO-1 and exert cytoprotective and anti-inflammatory activities via HO-1-ependent machanism.

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