pH-Sensitive Curdlan Acetate Microspheres를 이용한 Indomethacin의 방출 특성

Curdlan acetate was prepared from hydrophilic curdlan by chemical modification and it was used for pH-sensitive drug delivery system. Curdlan acetate microspheres were prepared by the solvent evaporation method. The size of the curdlan acetate microspheres was below $200\;{\mu}m$. The drug loading efficiency of microspheres was approximately 58.44%. In the swelling test, curdlan acetate microspheres were showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, Release rate of indomethacin (IND) at pH 7.4 from curdlan acetate microspheres was faster than that at pH 1.4. A pH-sensitive drug release pattern was due to the disintegrating after swelling.

생분해성인 Curdlan을 이용하여 pH 의존성 약물 전달계 개발을 위한 실험을 수행한 결과, pH 1,4에서 약물 방출 보다 pH 7.4에서 약물 방출이 10배 이상 증가하였다. 이러한 결과로 curdlan acetate microsphere는 pH 의존성 약물 전달계로 유용하다고 판단된다.