한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
권호 표지

Molecular analysis on the ODC antizyme from flounder (Parlichthys olivaceus)

  • Seo, Yong-Bae (Department of Microbiology, Pukyong National University) ;
  • Lee, Jae-Hyung (Department of Microbiology, Pukyong National University) ;
  • Kim, Young-Tae (Department of Microbiology, Pukyong National University)
  • Published : 2003.04.11
Download PDF
⟨ Previous Next ⟩

Abstract

Ornithine decarboxylase (ODC) is a key enzyme on the regulation of cellular polyamines. ODC antizyme is a protein that represses ODC through accelerating enzymatic degradation by the 26S proteasome. We have isolated two distinct antizyme cDNA clones (AZS and AZL) from a brain cDNA library constructed with flounder (Paralichthys olivaceus). AZS and AZL cDNA clones were encoding 221 and 218 residues long respectively and revealed 57.7% amino acids sequence identity. The presence of two antizymes mRNA were detected in brain, kidney, liver, and embryo.

Keywords