Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.248.3-249
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- 2003
Galactosylated PEI-PEG as nonviral gene transfer agent for hepatocyte targeting and imaging probe
- Kim, Eun-Mi (Chonnam national university, Department of pharmacy) ;
- Oh, In-Joon (Wonkwang university. Department of nuclear medicin) ;
- Jeong, Hwan-Jeong (Wonkwang university. Department of nuclear medicin) ;
- Shin, Sang-Chul (Wonkwang university. Department of nuclear medicin) ;
- Lee, Yong-Bok (Wonkwang university. Department of nuclear medicine)
- Published : 2003.10.01
Abstract
Objectives: Galatosylated PEI was synthesized and characterized for gene delivery to hepatocytes. It was modified by conjugating with hydrophilic PEG to improve in vivo circulation. And we studied the possibility as an imaging modality for monitoring of gene delivery using gal-PEI derivatives. Methods: The substitution values of galactose in PEI were calculated by resorcinol/sulfuric acid method and quantity of PEG was calculated by comparing NMR peak. Cytotoxicity was determined by MTT. (omitted)
Keywords