The Effect of Quercetin on the Pharmacokinetics of Paclitaxel in Rats

The purpose of this study was to investigate the effect of quercetin(2.0, 10, 20 mg/kg; combined or pretreated) on the pharmacokinetic parameters and the bioavailability of paclitaxel(50mg/kg) orally in rats. The plasma concentration of paclitaxel pretreated with quercetin(pretreated group) were increased significantly (p＜0.01) compared to that of control, but those of paclitaxel combined with quercetin(combined group) were not affected. Area under the plasma concentration-time curve (AUC) of paclitaxel pretreated with quercetin was significantly (p＜0.01) higher than that of control. (omitted)