대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.244.2-244.2
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- 2003
Pharmacokinetic disposition of apicidin possessing histone deacetylase inhibiting activities
- Shin, Beom-Soo (College of pharmacy, Sungkyunkwan University) ;
- Jun, Yoon-Sik (College of pharmacy, Sungkyunkwan University) ;
- Kim, Chul-Hwan (College of pharmacy, Sungkyunkwan University) ;
- Yoo, Sun-Dong (College of pharmacy, Sungkyunkwan University)
- 발행 : 2003.10.01
초록
The objective of this study was to characterize the absorption and pharmacokinetic disposition of novel cyclic tetrapeptide, apicidin, in rats. Apicidin was administered to SD rats by i.v. bolus injection (1,2 or 4 mg/kg) and oral gavages (10 mg/kg). Serum levels of apicidin were monitored by LC/MS over 8 hours following each administration. Upon i.v. injection, serum levels of apicidin were best fit by a multi-exponential equation. The t
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