Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.243.2-244
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- 2003
Toxicokinetics of CJ-11555: Gender Difference and Minimum Accumulation
- Kim, Il-Hwan (R&D center of Pharmaceuticals, CJ Corporation) ;
- Noh, Hyun-Jung (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Park, Jae-Mook (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Kim, Deog-Yeor (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Park, Jie-Eun (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Lee, Sung-Hak (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Kim, Taek-Rho (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Kim, Jin-Wan (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Kim, Young-Hoon (R&D center of Pharmaceuticals, CJ Corporation)
- Published : 2003.10.01
Abstract
Purpose: This study evaluated gender differences and extents of accumulation on chronic dose of CJ-1l555 using rats. Method: 0, 10, 50 and 200 mg/kg/day of CJ-11555 (0.5% CMC) were orally administered to rats for 28 days and observed toxicokinetic parameters. Plasma concentrations were analyzed by LC-MS/MS Result: Exposure to CJ-11555 increased with the increase in dose level for both sexes. Mean concentrations at 10 and 50 mg/kg/day were generally similar an Days 1 and 28, but were generally highter on Day 28 than on Day 1 at 200 mg/kg/day. (omitted)
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