대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.242.3-243
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- 2003
Study on the Protein Binding of Anti-cancer Agent, 2"-O-benzoylcinnamaldehyde, using Ultrafilteration and Flurescence Spectrometry
- Ren , Shan (College of Parmacy,Pusan National University, College of Pharmacy, Seoul National University) ;
- Kim, Dae-Duk (College of Parmacy,Pusan National University, College of Pharmacy, Seoul National University) ;
- Lee, Chi-Ho (College of Parmacy,Pusan National University, College of Pharmacy, Seoul National University)
- 발행 : 2003.10.01
초록
The compound of 2"-O-benzoylcinnamaldehyde(CB-ph) is a derivative of 2"-hydroxycinnamaldehyde whcih is a methanol extract of cinnamomum cassia blume. It"s a new anti-cancer agent which has been showed to inhibit the growth of various tumor cells in vitro and in vivo. In order to investigate the effective drug concentration and bio-distribution of CB-ph, the plasma protein binding was studied. In this study, the degree of the binding of Cb-ph to various serum proteins, the binding parameters, the binding site of CB-ph in human serum albumin, and the effect of some extensive protein-binding drugs on the protein binding of CB-ph in human serum ablumin were investigated respectively by ultrafilteration and fluorescence spectrometry. (omitted)
키워드