Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

New Analytical Method of Methyltestosterone in Human Serum by Gas Chromatography/Maa Spectrometry for Pharmacokinetics and Bioequivalence Studies in Human Volunteers

  • Kim, Hye-Jung (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology,seoul 136-791) ;
  • Bae, Sung-Seok (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology,seoul 136-791) ;
  • Myung, Seung-Woon (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology,seoul 136-791) ;
  • Ryu, Jae-Chun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology,seoul 136-791) ;
  • Chung, Youn-Bok (College of Pharmacy, Chungbuk National University, Chungbuk 361-763) ;
  • Kwon, Oh-Seung (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology,seoul 136-791)
  • Published : 2003.10.01
Download PDF
⟨ Previous $\textrm{Dompi}^{?}$" Tablets Containing Domperidone Maleate in Healthy Korean Volunteers" href="/article/CFKO200311922689659.page"> Next ⟩

Abstract

A simple, specific and sensitive method for the determination of methyltestosterone (MT) in human serum has been developed by gas chromatography/mass spectrometry with the purpose of conducting pharmacokinetic and bioequivalence studies of MT. This method involves the use of liquid-liquid extraction with diethyl ether and derivatization with MSTFA, using 1 ml of serum obtained from volunteers orally taken 50 mg MT. MT showed good resolutions in this conditions and no significant interfering peaks were observed. (omitted)

Keywords