대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.241.1-241.1
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- 2003
Pharmacokinetics of CJ-11555:Improvement of Bioavailability
- Noh, Hyun-Jung (R&D center of Pharmaceuticals, CJ Corporation) ;
- Kim, Il-Hwan (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Choi, Jae-Mook (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Kim, Deog-Yeor (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Park, Jie-Eun (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Choi, Kwang-Do (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Yeon, Kyu-Jeong (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Lee, Sung-Hak (R&D center of Pharmaceuticals, CJ Corporatio) ;
- Kim, Taek-Rho (R&D center of Pharmaceuticals, CJ Corporation)
- 발행 : 2003.10.01
초록
Purpose: The objective of the study was to elucidate the pharmacokinetics of CJ-11555, anti-cirrhotic agent, in different physical properties and vehicles. Methods: 8-week-old male intact rats were administered CJ-11555 either intravenously (20 mg/0.6 mL/kg, NMP:PEG400, 1:1) or orally (50 mg/2 mL/kg, various vehicles). Different particle sizes of CJ-11668 and various vehicles were applied to characterize CJ-11555 in vivo. Following the administration in rats, the plasma concentrations were determined by HPLC. (omitted)
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