Skin Permeation and Crosslinking of a Biological Tissue with Hydrolyzed Product of Gardeniae Fructus

For the purpose to treatment of skin disease genipoiside and hydrolyzed product of Gardeniae Fructus were studied on skin permeation and crosslinking of a biologied tissue. Geniposide was hydrolyzed to genipin by ${\beta}$-glucosidase and the rate of hydrolysis was rapid on the condition of high temperature of medium and high concentration of ${\beta}$-glucosidase. The permeation enhancing effects of geniposide and genipin under cream and gel preparations were tested using Franz type diffusion cell and the skin of hairless mouse. (omitted)