Skin penetration enhancement of prostaglandin El and its ethyl ester for topical formulations

  • Kim, Hee-Kyu (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
  • Kim, Jong-Seok (GUJU Pharma CO. LT) ;
  • Yang, Sung-Woon (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
  • Choi, Han-Gon (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
  • Yong, Chul-Soon (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
  • Choi, Young-Wook (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756)
  • Published : 2003.10.01

Abstract

Purpose. To investigate the effect of different terpene enhancers on skin penetrations of prostaglandin El (PGE1) and its ethyl ester (PGE1-EE), a therapeutic agent for erectile dysfunction, external gel systems were formulated with the specific enhancers having different values in their lipophilicity (log P was ranged in 2.23-4.58). Methods. Topical gels containing PGEl (0.5 %) and PGEl-EE (0.1 %) were formulated with ethanol and propylene glycol as a vehicle, selective terpenes as a penetration enhancer, and HPC-H as a thickening agent. (omitted)

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