대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Determination of Eupatilin in Human Plasma by Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry

  • Lee, Hye-Won (College of Pharmacy, Wonkwang University) ;
  • Ji, Hye-Young (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
  • Kim, Hui-Hyun (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
  • Kim, Sook-Jin (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
  • Kim, Soon-Hoe (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
  • Kim, Won-Bae (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
  • Lee, Hye-Suk (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905)
  • 발행 : 2003.10.01
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초록

A rapid, sensitive and selective liquid chromatography-tandem mass spectrometric (LC/MS/MS) method for the determination of eupatilin in human plasma was developed. Eupatilin and internal standard, (S)-[N-3-(4-(2-(1-methyl-5-tetrazolyl)-pyridine-5-y1)- 3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl acetamide (DA-7867) were extracted from human plasma by liquid-liquid extraction and analyzed on a phenyl-hexyl column with the mobile phase of acetonitrile-ammonium formate (10 mM, pH 3.0) (60:40, v/v). (omitted)

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