대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.217.2-217.2
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- 2003
Determination of a Novel Antiangiogenic Agent KR-31831 in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry
- Kim, Sook-Jin (Wonkwang University) ;
- Lee, Seung-Seok (Korea Research Institute of Chemical Technolog) ;
- Ji, Hye-Young (Department of Chemistry, Daejeon universit) ;
- Lee, Hong-Il (Department of Chemistry, Daejeon universit) ;
- Lee, Seon-Kyoung (Department of Chemistry, Daejeon universit) ;
- Yi, Kyu-Yang (Department of Chemistry, Daejeon universit) ;
- Yoo, Seong-Eun (Department of Chemistry, Daejeon universit) ;
- Hwang, Jeong-Sook (Department of Chemistry, Daejeon universit) ;
- Lee, Hye-Suk (Department of Chemistry, Daejeon university)
- 발행 : 2003.10.01
초록
A liquid chromatography-tandem mass spectrometric (LC/MS/MS) method was developed for the determination of a new anti-angiogenic drug KR-31831 in rat plasma. KR-31831 and internal standard, KR-31543 were extracted from rat plasma with dichloromethane at basic pH. A reverse-phase LC separation was performed on Luna C8 column with the mixture of acetonitrile-ammonium formate (10 mM, pH 4.5) (67:33, v/v) as mobile phase. The detection of analytes was performed using an electrospray ionization tandem mass spectrometry in the multiple-reaction-monitoring mode. (omitted)
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