대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.213.2-213.2
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- 2003
A Rapid Quantitative Assay of Intact Ambroxol Tablets by FT-NIR Spectroscopy
- Kim, Do-Hyung (College of Pharmacy, Dongduk Women's University) ;
- Ah, Woo-Young (College of Pharmacy, Dongduk Women's University) ;
- Kim, Hyo-Jin (College of Pharmacy, Dongduk Women's University)
- 발행 : 2003.10.01
초록
A simple analytical procedure using FT-NIR for the rapid determination of individual ingredients was evaluated. Direct measurements were made by reflection using a reflectance accessory, by transmittance using tablet accessory and turn table. FT-NIR spectral data were transformed to the first derivative. Partial Least Square Regression(PLSR) was applied to quantify near-infrared (NIR) spectra of 2 ingredients. These calibration models were cross-validated (leave-one-out approach). The prediction ability of the models was evaluated on ambroxol tablets and compared with the real values in manufacturing procedure. (omitted)
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