Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.207.3-208
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- 2003
Inhibitory effects of Saiko-ka-Ryukotsu-Borei-To on the migration and proliferation of vascular smooth muscle cell and suppression of carotid intimal thickness after balloon injury in rats
- Chung, Hwa-jin (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University) ;
- Maruyama Ikuro (College of Pharmacy, Ewha Womans University) ;
- Tani Tadato (School of Medicine, Kagoshima University) ;
- Lee, Sang-Kook (nstitute of Natural Medicine, Toyama Medical and Pharmaceutical University)
- Published : 2003.10.01
Abstract
Objectives:We have reported that oral administration of Saiko-ka-Ryukotsu-Borei-To (SRB), a traditional Chinese formulation, inhibited the intimal thickening in carotid artery after balloon injury in cholesterol-fed rats. To elucidate its mechanism, the effects of SRB on migration and proliferation of vascular smooth muscle cell (VSMC) were examined in vivo and in vitro.Methods: ＜ In vivo-study＞ Rats were fed on diet containing 1% cholesterol and SRB 3 days before and 4 days after denudation. Simvastatin was used as a positive control. (omitted)
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