대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Platelet Anti-aggregating Triterpene and Sterol Constituents from the Leaves of Acanthopanax senticosus

  • Jin, Jing-Ling (Natural Products Research Institute, Seoul National University, Seoul 110-460) ;
  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University, Seoul 110-460) ;
  • Lee, Yong-Yook (Natural Products Research Institute, Seoul National University, Seoul 110-460) ;
  • Kim, Jeong-Mi (Natural Products Research Institute, Seoul National University, Seoul 110-460) ;
  • Heo, Jung-Eun (Natural Products Research Institute, Seoul National University, Seoul 110-460) ;
  • YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University, Seoul 110-460)
  • 발행 : 2003.10.01
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초록

From methanol extract of Acanthopnanax senticosus, six platelet anti-aggregating compounds, chiisanogenin (1), chiisanoside (2), ursolic acid (3), oleanolic acid (4), b-sitosterol (5) and daucosterol (6) were isolated. All of the isolated compounds showed dose-dependent inhibitory activities to rat platelet aggregation induced by all the agonist employed. Compound 1 showed about 50 folds higher potency than acetylsalicylic acid (ASA) on U46619 induced platelet aggregation (IC$\sub$50/ : 6.21 ${\mu}$M) and 10 ∼ 20 folds higher effect than ASA on epinephrine and arachidonic acid (AA) induced aggregation (IC$\sub$50/ ; 2.50 and 4.81 ${\mu}$M, respectively). (omitted)

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