Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.205.1-205.1
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- 2003
Neuroprotective effects of Hexane fraction of M61 on Delayed Neuronal Death after Transient global Ischemia in Gerbil Hippocampus
- Kim, Haw-jung (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
- Kang, Hoon-Je (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
- Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
Several lines of recent evidences have shown that several pro-inflammatory genes or mediators, such as inducible nitric oxide synthase (iNOS)are strongly expressed in the ischemic brain. Inflammation is now recognized as a significant contributing mechanism in cerebral ischemia because anti-inflammatory compounds or inhibitors of iNOS have been proven to reduce ischemic brain damage. In iNOS assay, hexane fraction of M61 inhibited NO (iNOS IC50, 0.7
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