대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Anti-Oxidant and Hepato-protective Activities of the Stems of Acanthopanax senticosus

  • Son , Dong-Wook (R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd) ;
  • Ryu , Ji-Young (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kang , Jun-Gil (Seokwon Life Science Research Institute, World Sea Green Co. Lt) ;
  • Lee, Sang-Yun (Seokwon Life Science Research Institute, World Sea Green Co. Lt) ;
  • Kim, Hyun-Su (Seokwon Life Science Research Institute, World Sea Green Co. Lt) ;
  • Lee, Sang-Hyun (Seokwon Life Science Research Institute, World Sea Green Co. Lt) ;
  • Hoon, Jung-Sang (Seokwon Life Science Research Institute, World Sea Green Co. Lt) ;
  • Lee, Yeon-Sil (Seokwon Life Science Research Institute, World Sea Green Co. Lt) ;
  • Shin, Kuk-Hyun (Seokwon Life Science Research Institute, World Sea Green Co. Ltd)
  • 발행 : 2003.10.01
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초록

The anti-oxidant activities of Acanthopanax senticosus stems were investigated. The n-BuOH fraction of A. senticosus stems exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCl$_4$-intoxication in rats. The n-BuOH fraction inhibited the sGPT activities by 65.79%. The n-BuOH fraction showed the increase in the anti-oxidant enzymes such as hepatic cytoso1ic superoxide dismutase, catalase and glutathione peroxidase activities by 30.31, 19.82 and 155%, respectively, in CCl$_4$-intoxicated rats. These results suggest that the stems of A. senticosus possess not only the hepatoprotective, but also the anti-oxidant activities in rats.

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