대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.186.2-186.2
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- 2003
Synthesis of TZD Analogs as PPAR${\gamma}$ Specific Ligands
- Lee, Soo-Mi (Sookmyung Women's University) ;
- Lee, Sun-Mi (Sookmyung Women's University) ;
- Jeon , Raok (Sookmyung Women's University)
- 발행 : 2003.10.01
초록
PPARs (peroxisome proliferator activated receptors) are member of nuclear hormone receptors superfamily. Activations of PPARs upon binding with ligands modulate glucose metabolite, differentiation of adipocyte, inflammation response, and so on. Thiazolidinedione analog is one of the potential antidiabetic drug that binds and activates PPAR selectively and enhances insulin sensitivity. In an effort to develop novel and effective antidiabetic thiazolidindione analogs, we have synthesized tetrahydroquinoline and para-substituted benzene-linked thiazolidinedione analogs by coupling reaction of the hydrophobic segments with hydroxybenzylthiazolidinedione.
키워드