Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.185.3-185.3
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- 2003
Antifungal activities of juglone and naphthazarine derivatives
- Chae, Mi-Jin (College of Pharmacy, Ewha Womans University) ;
- Choi, Ik-Hwa (College of Pharmacy, Ewha Womans University) ;
- Han, Ja-Young (College of Pharmacy, Ewha Womans University) ;
- Jong, Ok-Jai (College of Pharmacy, Ewha Womans University) ;
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University)
- Published : 2003.10.01
Abstract
Juglone and naphthazarine derivatives were newly systhesized for the evaluation of antifungal activities. These derivatives were prepared by methylation of juglone and 2, 3-dichloro-5, 8-dihydroxy-l, 4-naphthoquinone, and by regioselective nucleophilic subsitution with arylthiols. All compounds were tested in vitro for their growth inhibitory activities against pathogenic fungi by the standard method. The MIC values were determined by comparison to flucytosine as a standard agent. (omitted)
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