Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.181.4-182
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- 2003
Synthesis of 6-Formyl-pyridine-2-carboxylate Derivatives and their Telomerase Inhibitory Activities
- Jew, Sang-Sup (Seoul National University, College of Pharmacy) ;
- Park, Boon-Saeng (Yonsei University, Department of Biolog) ;
- Lim, Doo-Yeon (Chong Kun Dang Pharmaceutical Co.) ;
- Kim, Myoung-Goo (Chong Kun Dang Pharmaceutical Co.) ;
- Chung, In-Kwon (Chong Kun Dang Pharmaceutical Co.) ;
- Kim, Joo-Hee (Chong Kun Dang Pharmaceutical Co.) ;
- Hong, Chung-Il (Chong Kun Dang Pharmaceutical Co.) ;
- Kim, Joon-Kyum (Chong Kun Dang Pharmaceutical Co.) ;
- Park, Hong-Jun (Chong Kun Dang Pharmaceutical Co.) ;
- Lee, Jun-Hee (Chong Kun Dang Pharmaceutical Co.) ;
- Park, Hong-Jun (Chong Kun Dang Pharmaceutical Co.) ;
- Lee, Jun-Hee (Chong Kun Dang Pharmaceutical Co.) ;
- Park, Hyeung-Geun (Chong Kun Dang Pharmaceutical Co.)
- Published : 2003.10.01
Abstract
Telomeres are DNA-protein complexes at the ends of chromosomes, which play an essential protective role against DNA degradation and aberrant recombination during cell divisions. Several telomerase inhibitors have been reported as candidates for new antitumor drugs. Among them, 2-thiobenzylpyridines, developed by Geron. Co Ltd. as a telomerase inhibitor, were chosen as lead compounds. Twenty-one pyridine-2- carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. (omitted)
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