대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.178.2-178.2
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- 2003
Total synthesis of 1,4-Dideoxy-1,4-Imino-D-Arabinitol(DABl)
- Kim, In-Su (College of pharmacy, Sungkyunkwan university) ;
- Jung, Young-Hoon (College of pharmacy, Sungkyunkwan university)
- 발행 : 2003.10.01
초록
Naturally occurring sugar mimics with a nitrogen in the ring are classified into five structural classes: polyhydroxylated pyrrolidines, piperidines, indolizidines. pyrrolizidine, and nortropanes. Glycosidase are involved in a wide range of important biological processes, such as intestinal digestion, post-translational processing of glycoproteins and the lysosomal catabolism of glycoconjugate. The realization that alkaloidal sugar mimics might have enormous therapeutic potential in many diseases such as viral infection, cancer and diabetes has led to increasing interest and demand for these compounds. (omitted)
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