Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.168.2-168.2
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- 2003
Screening and Characterization of Novel Akt/PKB inhibitors, SWU5 and SWU9
- Ko, Jong-Hee (ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd.) ;
- Yeon, Seung-Woo (Department of Chemistry, Seoul Women's University) ;
- Lee, Hong-Sub (Department of Biology, Myongji University) ;
- Kim, Tae-Yong (Department of Science Education, Chungbuk National University) ;
- Noh, Dong-Youn (Department of Science Education, Chungbuk National University) ;
- Shin, Kyong-Soon (Department of Science Education, Chungbuk National University) ;
- Hong, Soon-Kwang (Department of Science Education, Chungbuk National University) ;
- Kang, Sang-Sun (Department of Science Education, Chungbuk National University)
- Published : 2003.10.01
Abstract
Akt/Ptotein Kinase B (PKB) is a serine/threonine kinase and activated by PI3K pathway. Akt/PKB regulates a variety of cellular responses including proliferations, differentiations and insulin signaling pathway. Recent evidence also indicates that the abnormal activities or expression of Akt/PKB is closely associated with cancer, diabetes and neuro-degenerative diseases. These findings mean that Akt/PKB is likely to be a new therapeutic target for the treatment of disease. (omitted)
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