Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.165.3-166
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- 2003
The two-tiered activation of JNK1 prolongs cell survival prior to induced apoptosis
- Chun, Kwang-Hoon (College of pharmacy, Seoul National University) ;
- Ham, Young-Mi (College of Pharmacy, Kyung Hee University) ;
- Park, Joon-Seok (College of Pharmacy, Kyung Hee University) ;
-
Kim, Dong-Hyun
(College of Pharmacy, Kyung Hee University)
;
- Lee, Seung-Ki (College of Pharmacy, Kyung Hee University)
- Published : 2003.10.01
Abstract
The c-Jun N-terminal kinase (JNK) plays essential roles in apoptosis and cell survival. Because apoptosis is promoted by blocking the MEK kinase1-mediated activation of JNK1, we tested whether JNK1 plays dual roles in apoptosis. We show here that JNK1 activity is differentially up-regulated in a two-tiered fashion by specific mechanisms during taxol- or ginsenoside Rh2-induced apoptosis. The early phase of JNK1 activation, but not apoptosis is prevented by expressing the dominant negative SEK1 mutant. (omitted)
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