Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.163.1-163.1
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- 2003
Studies on the inhibition activities of various adenosine derivatives on S-adenosylhomocysteine hydrolase
- Lee, Hyun-Joo (College of Pharmacy, Ewha Womans University) ;
- Lee, Kang-Man (College of Pharmacy, Ewha Womans University) ;
- Shin, Jeong-Lak (College of Pharmacy, Ewha Womans University)
- Published : 2003.10.01
Abstract
The inhibitory activities of various analogues of adenosine (Group I, Group II, Group III, Group IV, Group V) were assayed by using recombinant human placental SAH hydrolase. The activity of the SAH hydrolase was determined by measuring the formation of AdoHcy from Ado and Hcy. AdoHcy was analyzed by HPLC using C18 reverse-phase column. The peak of AdoHcy was monitored at 258 nm. Among the tested compounds, fluoroneplanocin A (LJ-276) was the most potent inhibitor.
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