대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.159.2-159.2
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- 2003
Codonoposide $1_c$ is a potent inducer of apoptosisin Human Leukemia cell line, HL-60.
- Lee, Kyung-Won (College of Pharmacy, Kyung Hee University) ;
- Lee, Kyung-Tae (College of Pharmacy, Sangji University) ;
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Park, Hee-Juhn
(College of Pharmacy, Sangji University) ;
- Choi, Jong-Won (College of Pharmacy, Sangji University)
- 발행 : 2003.10.01
초록
Codonopside lc is an active natural compound isolated from the roots of Codonopsis lanceolata (Campanulaceae), a Korean medicinal herb. In the present study, we investigated the in vitro effect of Codonopside 1c on the proliferation and induction of apoptosis in HL-60 human promyelocytic cells. When HL-60 cells were treated with Codonopside 1c, evidence of apoptotic features, including DNA fragmentation, formation of DNA ladder in agarose gel elecrophoresis and increse of annexin V binding, were obtained. (omitted)
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