대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.158.2-158.2
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- 2003
Involvement of Akt in mitochondria-dependent apoptosis induced by a naphthoquinone analog
- Kang, Seung-Koo (Department of Immunology, College of Pharmacy, Chung-Ang University) ;
- Kim, Hae-Jong (Department of Immunology, College of Pharmacy, Chung-Ang University) ;
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Chun, Young-Jin
(Department of Immunology, College of Pharmacy, Chung-Ang University) ;
- Kim, Mie-Young
- 발행 : 2003.10.01
초록
Vitamin K-related analogs induce growth inhibition in various cancer cell lines. We report that 2,3-dichloro-5,8-dihydroxy-1, 4-naphthoquinone (DDN), a naphthoquinone analog, induces mitochondria-dependent apoptosis in human promyeloid leukemic HL-60 cells. DDN induced cytochrome c release, cleavage of Bid, and activation of caspases -8, -9 and -3. Cleavage of Bid, the caspase-8 substrate, was inhibited by the broad caspase inhibitor zVAD-fmk, whereas cytochrome c release was not affected by zVAD-fmk. (omitted)
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