Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.155.1-155.1
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- 2003
Antioxidant actions of polyphenol QGR and its building blocks on unopsonized zymosan-induced oxidative stress in murine macrophages Raw264.7
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Kim, Byung-Hak
(College of Pharmacy, Chungbuk National University)
;
- Reddy, A.M. (College of Pharmacy, Chungbuk National University) ;
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Min, Kyung-Rak
(College of Pharmacy, Chungbuk National University)
;
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Kim, Young-Soo
(College of Pharmacy, Chungbuk National University)
- Published : 2003.10.01
Abstract
Polyphenol QGR (quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside) was isolated from Persicaria lapathifolia (Polygonaceae). In this study, we investigated inhibitory effects of QGR and its building blocks (quercitrin, quercetin and gallic acid) on superoxide anion and NO productions in unopsonized zymosan-stimulated murine macrophages Raw264.7. QGR and quercetin showed potent inhibitory effects on unopsonized zymosan-induced superoxide anion production with IC50 values of 3.2 uM and 4.8 uM, respectively. (omitted)
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