Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.143.2-144
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- 2003
Celecoxib Attenuates Nitric Oxide-Induced Apoptosis in PC12 Cells by Inhibiting AP-1 Activation and COX-2 Expression.
- Li, Mei-Hua (College of pharmacy, Seoul National University) ;
- Jang, Jung-Hee (College of pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
Recent studies suggest that inflammatory events are implicated in a variety of ailments such as cancer and neurodegenerative diseases, and certain non-steroidal anti-inflammatory drugs have beneficial effects for the treatment or prevention of these disorders. Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the prostaglandin (PG) synthesis, is induced by various pro-inflammatory stimuli including nitric oxide (NO) and has been reported to cause and/or aggravate neuronal cell death. (omitted)
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