대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.142.2-142.2
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- 2003
Expression of osteopontin and this role in hepatic stellate cell motility and wound healing migration
- Lee, Sung-Hee (Department of Pharmacy, Wonkwang University) ;
- zhe, Zhao-Yu (Department of Pharmacy, Wonkwang University) ;
- Park, Eun-jeon (Department of Pharmacy, Wonkwang University) ;
- Min, Song-Hye (Department of Pharmacy, Wonkwang University) ;
- Hwan, Sohn-Dong (Department of Pharmacy, Wonkwang University)
- 발행 : 2003.10.01
초록
The activation of the hepatic stellate cell (HSC) is a key step in liver fibrogenesis. We investigated the changes of global gene expression during activation in hepatic stellate cells using a rat cDNA microarray with 5, 000 sequence-verified clones. We identified osteopontin (OPN), a secreted matrix protein, as one of the upregulated factors. Northern analysis showed OPN mRNA was increasingly expressed during progressive activation of cultured rat HSCs and in models of experimental liver fibrosis. (omitted)
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