대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Inhibition of tyrosine phosphatases blocks plasma membrane blebbing during Fas- induced apoptosis of Jurkat T cells without affecting the cytotoxicity of Fas-ligation

  • Cho, Jun-Young (Korea Research Institute of Bioscience and Biotechnology, College of Pharmacy, Chungnam National University) ;
  • Kim, Kwang-Dong (Korea Research Institute of Bioscience and Biotechnology, College of Pharmacy, Chungnam National University) ;
  • Kho, Chang-Won (Korea Research Institute of Bioscience and Biotechnology, College of Pharmacy, Chungnam National University) ;
  • Park, Sung-Goo (Korea Research Institute of Bioscience and Biotechnology, College of Pharmacy, Chungnam National University) ;
  • Chung, Kyeong-Soo (Korea Research Institute of Bioscience and Biotechnology, College of Pharmacy, Chungnam National University) ;
  • Lim, Jong-Seok (Korea Research Institute of Bioscience and Biotechnology, College of Pharmacy, Chungnam National University)
  • 발행 : 2003.10.01
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초록

Plasma membrane blebs are observed in many types of apoptotic cells, but their processes of formation remain to be clarified. In the present study, we investigated whether there is a relationship between change of intracellular phosphotyrosine levels and biochemical apoptotic events in Jurkat T cells undergoing apoptosis by agonistic anti-Fas antibody. When Jurkat cells were treated with Fas-antibody in the presence or absence of pretreatment with sodium orthovanadate ($Na_3${VO}_4$), a phosphotyrosine phosphatase (PTPase) inhibitor, membrane blebs disappeared in orthovanadate-treated cells. (omitted)

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